For decades, scientists believed that depression was due to an imbalance of neurotransmitters (chemical signals) in the brain. We now know that this is not the whole story. People with depression have fewer connections between neurons, and their brains show abnormal patterns of activity in specific neural networks.

 

Ketamine promotes neuroplasticity—the brain’s ability to form new neural connections—which may help restore healthier patterns of brain activity and emotional regulation. Unlike most psychiatric medications, which attempt to balance levels of neurotransmitters, ketamine sets off changes in the brain that can lead to continued benefits even after the medication leaves your body.

 

People with trauma, anxiety, and depression have often built narratives about themselves and the world around them that were helpful at one point, but have become entrenched, have outlived their usefulness, and are now the source of much suffering. Think of these narratives like walls that were once built to protect you, but now actually imprison you. Given the chance to break free, where would you go? What would you see? What would you learn along the way?

 

Ketamine reduces the activity of the brain network that generates thoughts about ourselves (the "default mode network). Because of this, ketamine offers a temporary escape from these narratives. This "departure" from the ordinary state of consciousness can be the start of a healing journey. Ketamine alone, however, cannot do all the heavy lifting to help you get better. This is why the best and long-lasting effects of ketamine therapy are achieved with concurrent and specifically integrated therapy sessions.